5`-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2`,3`-diacetate
5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate
CAS: 162204-20-8
Molecular Formula: C19H26FN3O8
5`-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2`,3`-diacetate - Names and Identifiers
| Name | 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate |
| Synonyms | Capecitabine interMediate Capecitabine Intermediate 1 2',3'-Di-O-acetylcapecitabine 5-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2,3-diacetate 5'-Deoxy-5-fluoro-N-(pentyloxy)carbonyl]cytidine 2',3'-diacetate 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate 5'-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2',3'-diacetate 5`-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2`,3`-diacetate 5`-Deoxy-5-Fluore-N-[(Pentoyloxy)Carbonyl]Cytidine 2`,3`-Diacetate Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate, 5'- Cytidine,5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-, 2',3'-diacetate [1-(2,3-Di-O-acetyl-5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyriMidinyl]carbaMic Acid Pentyl Ester |
| CAS | 162204-20-8 |
| EINECS | 700-593-2 |
| InChI | InChI=1/C19H26FN3O8/c1-5-6-7-8-28-19(27)22-16-13(20)9-23(18(26)21-16)17-15(31-12(4)25)14(10(2)29-17)30-11(3)24/h9-10,14-15,17H,5-8H2,1-4H3,(H,21,22,26,27)/t10-,14-,15-,17-/m1/s1 |
5`-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2`,3`-diacetate - Physico-chemical Properties
| Molecular Formula | C19H26FN3O8 |
| Molar Mass | 443.42 |
| Density | 1.40±0.1 g/cm3(Predicted) |
| Melting Point | 100-102?C |
| Solubility | soluble in Methanol |
| Appearance | powder to crystal |
| Color | White to Almost white |
| pKa | 5.36±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.566 |
| Use | Capecitabine Intermediate |
5`-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2`,3`-diacetate - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29349990 |
5`-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2`,3`-diacetate - Reference Information
| overview | 5 '-deoxy-5-fluoro-N-[(pentoxy) carbonyl] cytidine 2',3 '-diacetate CAS number 62204-20-8, chemical formula C19H26FN3O8, molecular weight 443.42300, density 1.4g/cm3, refractive index 1.566. 5 '-deoxy-5-fluoro-N-[(pentoxy) carbonyl] cytidine 2',3 '-diacetate is a key intermediate in the synthesis of capecitabine, capecitabine (Capecitabine), chemical name: 5'-deoxy-5-fluoro-N-[(pentoxy) carbonyl] cytidine, developed by Swiss Roche Pharmaceutical Company (roche), in April 1998, Xeloda was approved for listing in the United States under the trade name Xeloda. In 2000, it was approved for import by SFDA, and the listed dosage form was tablets. |
| synthesis method | method 1:2 ',3'-di-O-acetyl -5 '-deoxy-5-fluoro-N-(n-amyl oxycarbonyl) cytidine (ie 5'-deoxy-5-fluoro-N-[(pentoxyl) carbonyl] cytidine 2 ',3'-diacetate) is prepared as follows: 2 ',3'-di-O-acetyl -5 '-deoxy-5-fluorocytidine is used as raw material, in the presence of any organic solvent and alkalizing agent in dichloromethane, dichloroethane, acetonitrile, N,N-dimethylformamide, acylation reaction with n-amyl chloroformate to generate 2',3 '-di-O-acetyl -5'-deoxy-5-fluoro-N-(n-pentyloxycarbonyl) cytidine; add water to extract and merge the organic phase; concentrate the organic phase under reduced pressure until the distillate flows out, add isopropyl ether and acetonitrile to the oil, after all dissolution at room temperature, slowly cool to 0~5 ℃ and then crystallide to obtain white powder 2 ',3'-di-O-acetyl -5 '-deoxy-5-fluoro-N-(n-pentyloxycarbonyl) cytidine (I. e. 5'-deoxy-5-fluoro-N-[(pentoxyl) carbonyl] cytidine 2 ',3'-diacetate), the reaction process is as follows: |
Last Update：2024-04-09 21:04:16
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View History
5`-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2`,3`-diacetate
Pyrazolo[1,5-a]pyrimidine, 7-chloro-6-(2-chloroethyl)-2,5-dimethyl-
Trans-4-cyano-3-fluorophenyl 4-ethylcyclohexanecarboxylate
RARECHEM BK HC T256
UNII-59375N1D0U
3',5'-O-(四异丙基二硅氧烷-1,3-二基)-2'-氧代尿苷
Pyrazolo[1,5-a]pyrimidine, 7-chloro-6-(2-chloroethyl)-2,5-dimethyl-
Trans-4-cyano-3-fluorophenyl 4-ethylcyclohexanecarboxylate
RARECHEM BK HC T256
UNII-59375N1D0U
3',5'-O-(四异丙基二硅氧烷-1,3-二基)-2'-氧代尿苷